Research toxicologist - New approaches for toxicity testing (m/f/d), Sophia

Bayer is an international group whose core businesses lie in the healthcare and agriculture sectors. At the intersection of chemistry and biology, Bayer helps to improve quality of life by offering products and services in human and plant health.

Missions

In the context of the new toxicity testing paradigm based on more animal or human based cell responses and a comprehensive mechanistic understanding of cause-consequence relationships for adverse effects induced by (agro)chemicals, your role will be to develop, implement and apply new alternative methodologies (NAMs):

• Design, develop, and implement new in vitro methodologies and high-content image-cell based assays for morphological profiling able to indicate potential in vivo adverse effects
• Establish toxicology and business relevant mediumto highthroughput in vitro test systems able to mimic the in vivo situation in order to quantify the risk in human beings
• Utilize advanced technologies to study biological and molecular processes: e.g., apply relevant biomarkers and use image analysis for quantification, perform biological assays to monitor cell behavior and function

Profile

• Biologist or Scientist with a PhD degree related to tissue engineering, biotechnology, biology, toxicology, or related disciplines.
• You have strong expertise in cellular models and morphological profiling (cell painting technologies). Proven hands-on experience with a variety cell based and molecular biology readouts technologies along with state-of-the-art imaging methods (immunostaining and confocal imaging, qPCR, flow cytometry, MSD, toxicogenomics etc.) will be looked at. Experience with experimental characterization and (ideally, mathematically) description of dose/concentration toxicity pathways would be a plus.